tag:blogger.com,1999:blog-4738062031052371885.post4767639526622620843..comments2024-03-17T10:07:53.205-07:00Comments on The Well-Rounded Mama: Antibiotic Underdosing in "Obesity"Well-Rounded Mamahttp://www.blogger.com/profile/04129621631406155340noreply@blogger.comBlogger6125tag:blogger.com,1999:blog-4738062031052371885.post-51807401530817277242010-08-31T10:31:07.294-07:002010-08-31T10:31:07.294-07:00I can't say I'm surprised. Researchers hav...I can't say I'm surprised. Researchers have made barely any effort to figure out how drugs affect women differently, and women are more numerous than "obese" people.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-4738062031052371885.post-69460253389283135762010-08-31T08:46:23.211-07:002010-08-31T08:46:23.211-07:00"One-size" dosing is a poor excuse to de..."One-size" dosing is a poor excuse to decline weight-based dosing -- surely it could be handled by a compounding pharmacy.Hazelnuthttps://www.blogger.com/profile/04952768656340372842noreply@blogger.comtag:blogger.com,1999:blog-4738062031052371885.post-9063850276231905982010-08-30T17:39:33.063-07:002010-08-30T17:39:33.063-07:00We also need to have weight based dosing in hormon...We also need to have weight based dosing in hormonal birth control. It's like an evil algebra problem. If I am 250 lbs and the medication's dosing is proven effective up to 230 lbs, and hormonal birth control is my only method of pregnancy prevention, then how long is it before I become pregnant?Sara A.noreply@blogger.comtag:blogger.com,1999:blog-4738062031052371885.post-56979869186293870872010-08-30T07:55:58.706-07:002010-08-30T07:55:58.706-07:00Thank you so much for writing about this. I was t...Thank you so much for writing about this. I was totally unaware of this crucial issue that could profoundly impact my health care. I will be discussing this with my doctors the next time I get ill and I hope that the research in this area continues and is utilized by doctors in the field sooner than the usual 15 year window it takes for research recommendations to be implemented in practice.Figure8onaDatehttp://kimocean.blogspot.com/noreply@blogger.comtag:blogger.com,1999:blog-4738062031052371885.post-70391043395983108902010-08-30T07:12:15.237-07:002010-08-30T07:12:15.237-07:00Nice essay! The primary consideration is whether t...Nice essay! The primary consideration is whether the drug is lipophilic or lipophobic (in the chemical sense, not the psychological sense!). Most antibiotics are hydrophilic (or lipophobic) and do not take residence in fat deposits. Vancomycin is an exception, and it is often given in critical situations such as cellulitis. I know many supersized people who have died of cellulitis, and I wonder how many times underdosing of lipophilic antibioltics may have contributed to their deaths.Paul Ernsbergernoreply@blogger.comtag:blogger.com,1999:blog-4738062031052371885.post-52291497117870061922010-08-30T04:50:23.173-07:002010-08-30T04:50:23.173-07:00wow thanks for this...enlightening and well writee...wow thanks for this...enlightening and well writeen...bravo! i wonder how many of us fatties die every year with complications from dosing, and how tht would effect the OMG fat will kill you stats the CDC likes to throw around (even though they were forced to change their numbers by a whole decimal point...but no one seems to have digested THAT information)Anonymousnoreply@blogger.com